Amino Acid Profile, Glycine Encephalopathy, Plasma and Cerebrospinal Fluid
Use
Diagnosis of glycine encephalopathy (nonketotic hyperglycinemia).
Special Instructions
For plasma and cerebrospinal fluid collected more than 20 minutes, order Amino Acid Profile, Quantitative, Plasma (700068) or Amino Acid Profile, Quantitative, Cerebrospinal Fluid (700180). To discuss amino acid testing options, please call 1-800-345-GENE and ask to speak to a Biochemical Geneticist.
Limitations
This test was developed and its performance characteristics determined by Labcorp. It has not been cleared or approved by the Food and Drug Administration. The test has specific specimen requirements; gross hemolysis, room temperature or thawed specimens, and specimens collected in ACD (yellow-top) tubes are causes for rejection. Plasma reference ranges will be applied to all specimen types.
Methodology
Mass Spectrometry
Biomarkers
LOINC Codes
- 73913-6
- 20644-1
- 22650-6
- 73913-6
- 49303-1
- 72486-4
- 49549-9
Result Turnaround Time
3-5 days
Related Documents
For more information, please review the documents below
Specimen
Plasma
Volume
0.5 mL
Minimum Volume
0.15 mL
Container
Preferred: Frozen plasma from green-top (sodium heparin) tube
Collection Instructions
Plasma and CSF should be simultaneously collected (venipuncture immediately prior to lumbar puncture). Separate plasma from cells. Transfer specimen to plastic transport tube before freezing.
Storage Instructions
Plasma: Centrifuge, remove plasma from cells, and freeze immediately.
Causes for Rejection
Gross hemolysis; room temperature or thawed specimen; specimens collected in ACD (yellow-top) tubes
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | Unstable |
| Refrigerated | Unstable |
| Frozen | 14 days |