Amitriptyline
Also known as: Elavil®, Endep®
Use
Evaluate toxicity; monitor therapeutic levels
Special Instructions
Specimens should be collected immediately prior to the next dose unless specified otherwise. Therapeutic drug monitoring accounts for factors such as co-medications, diet, smoking habit, and impaired organ function, and is complementary to pharmacogenetic genotyping.
Limitations
Developed by Labcorp, this test's performance characteristics have not been cleared or approved by the FDA. Tricyclic antidepressants have significant drug interactions, notably with antiepileptics and other CNS-active drugs. They should be avoided in pregnant and lactating women due to unestablished safety. Elderly patients are prone to postural hypotension, urinary retention, and sedation. Co-administration with MAO inhibitors is contraindicated.
Methodology
Mass Spectrometry
Biomarkers
LOINC Codes
- 43106-4
- 3333-2
- 3872-9
- 3335-7
Result Turnaround Time
2-5 days
Related Documents
For more information, please review the documents below
Specimen
Serum
Volume
1 mL
Minimum Volume
0.3 mL
Container
Red-top tube, lavender-top (EDTA) tube, or green-top (heparin) tube. Do not use a gel-barrier tube.
Collection Instructions
Transfer separated serum or plasma to a plastic transport tube.
Storage Instructions
Room temperature
Causes for Rejection
Gel-barrier tube
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 14 days |
| Refrigerated | 14 days |
| Frozen | 14 days |