Use

Leucine-rich glioma-inactivated 1 (LGI1) antibody encephalitis is a rare autoimmune voltage-gated potassium channel complex (VGKC) antibody-associated limbic encephalitis. Specifically, it is classified as an ant neuronal surface antigen- or ant-synaptic protein-associated autoimmune encephalitis. In addition to the common symptoms of limbic encephalitis such as cognitive impairment, seizures and psychiatric disorders, this disease is also associated with faciobrachial dystonic seizure (FBDS) and refractory hyponatremia. Unlike other limbic encephalitides, LGI1 antibody encephalitis is rarely accompanied by tumors and shows a good response to immunotherapy.