Anticardiolipin Antibodies (ACA), IgG, Quantitative
Also known as: Antiphospholipids, Cardiolipin Antibodies
Use
Anticardiolipin antibodies are often present in individuals with the antiphospholipid antibody syndrome.1,2
Special Instructions
Individuals who test positive for ACA should be retested after six to eight weeks to exclude transient antibodies that may not be clinically significant. ACA testing is recommended together with lupus anticoagulants (LA) testing due to the heterogeneity of antibodies associated with APS.
Limitations
Anticardiolipin antibodies can be observed during the convalescent phase of acute bacterial and viral infections, including syphilis, and may be transient. They are not necessarily associated with an increased risk of clinical complications. ACA testing alone should not be used to diagnose APS; repeat positive results at least six weeks apart are necessary for confirmation. Drug-induced ACA may also be present and need to be evaluated for clinical significance if persistent.
Methodology
Immunoassay (ELISA)
Biomarkers
LOINC Codes
- 3181-5
- 3181-5
Result Turnaround Time
1-3 days
Related Documents
For more information, please review the documents below
Specimen
Serum
Volume
1 mL
Minimum Volume
0.5 mL
Container
Red-top tube or gel-barrier tube
Storage Instructions
Room temperature
Causes for Rejection
Hemolysis; lipemia; icteric specimen
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 14 days |
| Refrigerated | 14 days |
| Frozen | 14 days |