Cardiolipin Antibodies, IgG, IgM, and IgA

Casandra

Casandra Test Code AR34803Version 1 (DRAFT)

Performing Lab

Lab ARUP LaboratoriesLab Test ID 0051162CPT Code 86147

Cardiolipin Antibodies, IgG, IgM, and IgA

Also known as: CARD PAN

Clinical Use

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Use

The test measures the presence of cardiolipin antibodies (IgG, IgM, IgA) which can be indicative of antiphospholipid syndrome (APS). Persistent moderate or high levels of these antibodies are a laboratory criterion for the diagnosis of APS. The presence of these antibodies may also occur in patients with clinical symptoms of APS, although their significance in lower positive levels remains undefined. Accurate diagnosis requires correlation with APS-specific clinical manifestations and other phospholipid antibody tests.

Special Instructions

This test is not recommended as a panel for diagnosing antiphospholipid syndrome (APS). Instead, the Cardiolipin Antibodies, IgG and IgM (0099344) test is preferred. Serum should be separated from cells as soon as possible or within two hours of collection and transferred to an ARUP Standard Transport Tube.

Limitations

The test should not be used alone for APS diagnosis due to the undefined significance of moderate to low antibody levels. Antibody presence needs confirmation through consistent results in specimens drawn at least 12 weeks apart. The test does not replace APS-specific criteria tests and should be used in conjunction with clinical evaluation.

Test Details

FDA Approved