Anticardiolipin Antibodies (ACA), IgA, IgG, IgM, Quantitative

Casandra

Casandra Test Code LC34719Version 1 (DRAFT)

Performing Lab

Lab LabcorpLab Test ID 161950CPT Code 86147

Anticardiolipin Antibodies (ACA), IgA, IgG, IgM, Quantitative

Also known as: Antiphospholipids, Cardiolipin Antibodies

Clinical Use

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Use

Anticardiolipin antibodies are often present in individuals with the antiphospholipid antibody syndrome.1,2

Special Instructions

Patients who test positive for ACA should be retested after six to eight weeks to rule out transient antibodies. ACA can also be observed in the convalescent phase of acute infections or in conditions like syphilis. Many transient ACA are not associated with APS, thus the diagnosis should not be based on a single ACA result. Retesting is important to establish persistence of antibodies.

Limitations

ACA can appear during acute bacterial or viral infections and in individuals with syphilis, often transient and not linked with increased clinical complication risk. Most are transient and don't indicate APS. False positives can occur, necessitating retesting for definitive diagnosis. Conditions like autoimmune disorders and malignancies can feature ACA, increasing APS risk. Drugs can induce ACA with potential clinical significance if persistent.

Test Details