Cardiolipin Antibody, IgA

Casandra

Casandra Test Code AR45508Version 1 (DRAFT)

Performing Lab

Lab ARUP LaboratoriesLab Test ID 0098358CPT Code 86147

Cardiolipin Antibody, IgA

Also known as: CARDIO IGA

Clinical Use

Order Test

Use

Cardiolipin Antibody, IgA testing is used in the evaluation of patients suspected of having Antiphospholipid Syndrome (APS), especially when seronegative. It aids in the diagnosis by identifying IgA antibodies against cardiolipin, which are phospholipids associated with APS. This assay is particularly useful in conjunction with other non-criteria antiphospholipid antibody tests to provide a more comprehensive assessment of APS risk.

Special Instructions

The test must be performed under refrigeration to maintain serum stability and avoid degradation. It requires prompt serum separation from cells, ideally within 2 hours of collection, to ensure accurate results. The test is approved for use by the New York Department of Health.

Limitations

This test is specifically for the detection of IgA class cardiolipin antibodies and may not detect other antiphospholipid antibodies important in APS diagnosis. It is not intended to replace clinical judgment and should be considered as part of a comprehensive diagnostic approach. False positives or negatives can occur due to interfering substances or improper specimen handling.

Test Details

New York Approved

Methodology

Immunoassay (ELISA)

Biomarkers

Cardiolipin Antibody, IgA • ELISA

LOINC Codes

Order Codes

5076-5

Result Turnaround Time

1-2 days

Specimen

Serum

Volume

1 mL

Minimum Volume

0.3 mL

Container

ARUP standard transport tube

Collection Instructions

Collect using a serum separator tube. Separate serum from cells ASAP or within 2 hours of collection and transfer to an ARUP standard transport tube.

Storage Instructions

Store and transport refrigerated. Ambient stability is 48 hours. Refrigerated stability is 2 weeks. Frozen stability is 1 year, avoiding repeated freeze/thaw cycles.