ATN Profile

Also known as: Alzheimer's, Amyloid-Tau-Neurodegeneration (ATN) Profile, Beta Amyloid 42/40 Ratio, Plasma, Neurofilament Light Chain(NfL), Plasma, Phosphorylated Tau 181 (pTau-181), Plasma

Clinical Use

Order Test

Use

This profile is used to assist in determining the presence or absence of key biological changes that are consistent with Alzheimer's disease pathology.

Special Instructions

Not provided.

Limitations

The tests included in the ATN Profile were developed and performance characteristics were determined by Labcorp; however, they have not been cleared or approved by the FDA. As these biomarkers are indicators of Alzheimer's pathology, they may not be specific and could potentially reflect similar changes in other neurodegenerative diseases. Additionally, the neurofilament light chain (NfL) as a marker of neurodegeneration is not disease-specific but indicative of axonal damage in general, limiting its specific application to Alzheimer's disease alone.

Test Details

Methodology

Immunoassay (Chemiluminescence Immunoassay)

Biomarkers

3 components

Beta Amyloid 42/40 Ratio • Chemiluminescence ImmunoassayPhosphorylated Tau 181 (pTau-181) • Electrochemiluminescence ImmunoassayNeurofilament Light Chain (NfL) • Electrochemiluminescence Immunoassay

LOINC Codes

Result Codes

106941-8 - Abeta42/ABeta40 Plas LC/MS/MS
33200-7 - AL beta42 Plas-mCnc
70073-2 - AL beta40 Plas-mCnc
103675-5 - p-tau181 Plas IA-mCnc
101281-4 - Nfl chain SerPl IA-mCnc

Result Turnaround Time

7-10 days

Specimen

Plasma

Volume

3 mL

Minimum Volume

2.5 mL

Container

Lavender-top (EDTA) tube, screw-capped frozen transport tube

Collection Instructions

Draw two full lavender-top (EDTA) tubes of blood. Separate plasma from blood via centrifugation (>1500g for 10 minutes) within 40 minutes after blood collection. Transfer plasma to two Labcorp polypropylene transport tubes and seal.

Storage Instructions

Plasma samples may be stored for up to 24 hours at < -10°C (standard freezer) prior to placing in dry ice, or samples may be stored in the refrigerator for up to 10 hours but then must be placed on dry ice for transport. All samples must be maintained on dry ice or similar temperatures.