BRCAssure®: BRCA2 Targeted Analysis

Casandra

Casandra Test Code LC57163Version 1 (DRAFT)

Performing Lab

Lab LabcorpLab Test ID 485081CPT Code 81217

BRCAssure®: BRCA2 Targeted Analysis

Clinical Use

Use

This test is intended for those individuals who have a family member with a known BRCA2 variant and wished to be tested only for that variant. A copy of the positive family member's laboratory report or genetic counseling letter documenting the variant is required for this testing. Only the specific region of the BRCA2 gene containing the familial variant will be tested. If the familial variant is a large deletion or duplication of BRCA2, BRCAssure®: BRCA1 and BRCA2 Deletion/Duplication Analysis [485050] should be ordered. If there is no family member with a known BRCA1 variant or if there is no documentation of the familial variant, BRCAssure®: BRCA1 and BRCA2 Comprehensive Analysis [485030] should be ordered. Please call 800-345-4363 for more information regarding documentation requirements or other questions.

Special Instructions

A BRCAssure® clinical questionnaire and documentation of the familial BRCA2 variant must be submitted with specimens. Contact CMBP genetics services at 800-345-4363 to coordinate testing. Oragene Dx 500 saliva collection kits can be ordered using PeopleSoft No. 87917 through your local Labcorp branch.

Limitations

This test does not detect germline mosaicism or large chromosomal aberrations like rearrangements, gene fusions, or variants outside the tested regions. It can't determine phase for heterozygous variants in the same gene. The presence of other hereditary cancer syndromes can't be ruled out.

Test Details