Chromosome Analysis, Leukemia/Lymphoma
Also known as: Chromosome Analysis, Hematologic Disorders, Lymphoma
Use
Karyotyping, physical localization of copy number changes, and mapping of breakpoints involved in translocations.
Special Instructions
Include a tentative diagnosis or treatment plan on the test request form to facilitate proper culturing and result interpretation. If the Plasma-enriched Multiple Myeloma (MM) Profile, FISH [510325] is ordered concurrently and the sample is insufficient for both tests, the FISH test will take priority.
Limitations
The use of lithium heparin or EDTA anticoagulants can inhibit cell culture growth, which would affect the test's outcomes. Only samples with more than 4% blasts are suitable, except in cases of CLL, hairy cell leukemia, and small-cell lymphocytic leukemia where β-mitogen stimulation can be applied. Nonnormative specimens, gross contamination, and clotted or fixed samples are causes for rejection. Also, this analysis may not detect clonal molecular alterations below the resolution of light microscopy; additional molecular or FISH testing may be necessary.
Methodology
Chromosomal / Cytogenetics (Karyotype)
Biomarkers
LOINC Codes
- 31208-2
- 62361-1
- 62360-3
- 55199-4
- 62358-7
- 62356-1
- 62365-2
- 48672-0
- 11502-2
Result Turnaround Time
7-10 days
Related Documents
For more information, please review the documents below
Specimen
Bone Marrow
Volume
2 mL
Minimum Volume
Not provided
Container
pediatric sodium heparin green-top tube
Collection Instructions
Submit bone marrow at room temperature using the Leukemia/Lymphoma Specimen Transport Kit provided by LabCorp. Indicate collection date and time on the test request form.
Storage Instructions
Maintain specimen at room temperature and ensure that it arrives at the laboratory within 48 hours of collection.
Causes for Rejection
Hemolysis; gross contamination; non-neoplastic cells; clotted specimen; frozen specimen; fixed specimen; improper or too much anticoagulant.