Clomipramine
Also known as: Anafranil®
Use
Evaluate toxicity; monitor therapeutic levels
Special Instructions
The major metabolite, norclomipramine, retains biologic activity. Specimens for therapeutic monitoring should be collected immediately before the next dose. It is crucial not to use gel-barrier tubes due to potential drug absorption by the gel.
Limitations
The LC/MS-MS methodology was developed and its performance characteristics determined by LabCorp, but it is not cleared or approved by the FDA. Metabolism of clomipramine may be dose-related and subject to enzyme inhibition from medications like valproic acid, which could lead to elevated clomipramine levels and potential seizures.
Methodology
Mass Spectrometry
Biomarkers
LOINC Codes
- 3491-8
- 3491-8
- 3536-0
- 3493-4
Result Turnaround Time
2-5 days
Related Documents
For more information, please review the documents below
Specimen
Serum
Volume
1 mL
Minimum Volume
0.3 mL
Container
Red-top tube, lavender-top (EDTA) tube, or green-top (heparin) tube
Collection Instructions
Transfer separated serum or plasma to a plastic transport tube. For therapeutic monitoring, collect specimen immediately prior to next dose.
Storage Instructions
Maintain specimen at room temperature.
Causes for Rejection
Gel-barrier tube
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 67 hours |
| Refrigerated | 14 days |
| Frozen | 14 days |