CNS Demyelinating Disease Evaluation Profile, Serum
Also known as: CNS Demyelinating Panel
Use
This test is beneficial for the initial assessment of inflammatory diseases involving demyelination in the central nervous system (CNS), which includes conditions like neuromyelitis optica spectrum disorder (NMOSD) and NMOSD-like disorders, as well as acute disseminated encephalomyelitiis (ADEM).
Special Instructions
Not provided.
Limitations
Results of this profile should be used in conjunction with clinical findings and other laboratory tests. The absence of both AQP4 IgG and MOG IgG antibodies does not exclude the diagnosis of NMOSD, and it is advisable to consider retesting before initiating antibody-targeted therapies.
Methodology
Cell-based / Cytometry (Flow Cytometry)
Biomarkers
LOINC Codes
- 95272-1 - AQP4 H2O channel IgG Ser Ql CBA IFA
- 91545-4 - MOG Ab Ser Ql CBA IFA
Result Turnaround Time
5 days
Related Documents
For more information, please review the documents below
Specimen
Serum
Volume
2 mL
Minimum Volume
1 mL
Container
Gel-barrier tube, red-top tube, serum transfer tube
Collection Instructions
Specimen should be free of bacterial contamination, hemolysis and lipemia.
Storage Instructions
Room temperature
Causes for Rejection
Hemolysis; lipemia; heat-treated specimen; gross bacterial contamination
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 14 days |
| Refrigerated | 14 days |
| Frozen | 14 days |
Other tests from different labs that may be relevant