Autoimmune CNS Demyelinating Disease Reflexive Panel
Use
The Autoimmune CNS Demyelinating Disease Reflexive Panel is used in the initial evaluation of inflammatory central nervous system (CNS) demyelinating diseases, including acute disseminated encephalomyelitis (ADEM), neuromyelitis optica spectrum disorder (NMOSD), and myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD). Antibodies to aquaporin-4 (AQP4) and myelin oligodendrocyte glycoprotein (MOG) are screened, which are associated with demyelinating disorders. Detection of these antibodies can help in the diagnosis and management of these conditions.
Special Instructions
If Aquaporin-4 Receptor Antibody, IgG by IFA with Reflex to Titer, Serum is positive, then an Aquaporin-4 Receptor Antibody, IgG by IFA, Serum Titer will be added. If Myelin Oligodendrocyte Glycoprotein (MOG) Antibody, IgG by IFA with Reflex to Titer, Serum is positive, then a Myelin Oligodendrocyte Glycoprotein (MOG) Antibody Titer, IgG will be added. Additional charges apply.
Limitations
This test is intended for clinical purposes and its performance characteristics were determined by ARUP Laboratories. It has not been cleared or approved by the US Food and Drug Administration. The presence of antibodies is diagnostic for NMO, but the absence of antibodies does not rule out a diagnosis of NMO or MOG-associated disorders. This test should be interpreted in conjunction with clinical findings and other laboratory data.
New York Approved
Methodology
Cell-based / Cytometry (Flow Cytometry)
Biomarkers
LOINC Codes
- 63439-4
- 91545-4
Result Turnaround Time
1-6 days
Related Documents
For more information, please review the documents below
Specimen
Serum
Volume
1 mL
Minimum Volume
0.3 mL
Container
Serum Separator Tube (SST)
Collection Instructions
Separate from cells ASAP or within 2 hours of collection. Transfer serum to an ARUP Standard Transport Tube.
Storage Instructions
Refrigerated.
Causes for Rejection
Hemolyzed, contaminated, or severely lipemic specimens.
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 48 hours |
| Refrigerated | 2 weeks |
| Frozen | 1 month (avoid repeated freeze/thaw cycles) |
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