DDAVP Challenge Profile for Von Willebrand Disease

Clinical Use

Use

This profile is designed to assess the response of DDAVP treatment in patients presenting with Von Willebrand Disease by measuring VWF and factor VIII levels pre-treatment (baseline) and at two time-points (1 hr and 4 hr) post-treatment. Post-treatment VWF levels are evaluated against baseline results to determine whether the response is adequate and sustained. Results should be correlated with clinical symptoms and family history.

Special Instructions

Not provided.

Limitations

The success of this profile in assessing DDAVP response is contingent on proper timing and handling of specimens. Incorrect sample handling or timing can skew results, making it critical to adhere strictly to the collection and processing instructions. Repeat testing may not be possible with minimum volume specimens.

Test Details

Methodology

Other

Biomarkers

9 targets

Factor VIII Act, Timepoint 1Factor VIII Act, Timepoint 2Factor VIII Act, Timepoint 3vWF Activity, Timepoint 1vWF Activity, Timepoint 2vWF Activity, Timepoint 3vWF Antigen, Timepoint 1vWF Antigen, Timepoint 2+1 more

LOINC Codes

Result Codes

21026-0 - Path Interp Bld-Imp
3209-4 - Fact VIII Act/Nor PPP
6014-5 - vWF Act/Nor PPP Aggr Rst act
27816-8 - vWF Ag Act/Nor PPP IA

Result Turnaround Time

3-5 days

Specimen

Plasma

Volume

2 mL per timepoint

Minimum Volume

1.5 mL per timepoint

Container

Blue-top (sodium citrate) tube

Collection Instructions

Centrifuge at 2500 xg for 10 minutes. Separate plasma from cells within 3 hours of venipuncture. Centrifuge plasma a second time and place in plastic transport tubes. Freeze within 4 hours and keep frozen until testing is performed.