DDAVP Challenge Profile for Von Willebrand Disease
Use
This profile is designed to assess the response of DDAVP treatment in patients presenting with Von Willebrand Disease by measuring VWF and factor VIII levels pre-treatment (baseline) and at two time-points (1 hr and 4 hr) post-treatment. Post-treatment VWF levels are evaluated against baseline results to determine whether the response is adequate and sustained. Results should be correlated with clinical symptoms and family history.
Special Instructions
This profile contains testing for FVIII Activity, VWF Activity and VWF Antigen at three timepoints: baseline, 1 hour and 4 hours post-treatment with DDAVP. It also contains a pathologist Interpretation of all test results.
Limitations
The success of this profile in assessing DDAVP response is contingent on proper timing and handling of specimens. Incorrect sample handling or timing can skew results, making it critical to adhere strictly to the collection and processing instructions. Repeat testing may not be possible with minimum volume specimens.
Methodology
Other
Biomarkers
LOINC Codes
- 21026-0
- 3209-4
- 6014-5
- 27816-8
Result Turnaround Time
3-5 days
Related Documents
For more information, please review the documents below
Specimen
Plasma
Volume
2 mL per timepoint
Minimum Volume
1.5 mL per timepoint
Container
Blue-top (sodium citrate) tube
Collection Instructions
Centrifuge at 2500 xg for 10 minutes. Separate plasma from cells within 3 hours of venipuncture. Centrifuge plasma a second time and place in plastic transport tubes. Freeze within 4 hours and keep frozen until testing is performed.
Storage Instructions
Plasma, frozen
Stability Requirements
| Temperature | Period |
|---|---|
| Frozen | 6 months |