Doxepin
Also known as: Adapin®, Silenor®, Sinequan®
Use
Evaluate toxicity; monitor therapeutic levels
Special Instructions
Tricyclic antidepressants have significant drug interactions and should be used with caution in conjunction with other medications. Tricyclics, including Doxepin, are potent inducers of hepatic drug-metabolizing enzymes and can interact with various substances, leading to altered drug efficacy.
Limitations
The test has not been cleared or approved by the FDA but has been developed and performance validated by Labcorp. Tricyclic antidepressants should be avoided in pregnant and lactating women due to the lack of established safety. Geriatric patients should be monitored for postural hypotension, urinary retention, and sedation. The test results may be influenced by the use of gel-barrier tubes, which are not recommended due to potential drug absorption and loss.
Methodology
Mass Spectrometry
Biomarkers
LOINC Codes
- 43122-1
- 3579-0
- 3862-0
- 3582-4
Result Turnaround Time
3-5 days
Related Documents
For more information, please review the documents below
Specimen
Serum
Volume
1 mL
Minimum Volume
0.3 mL
Container
Red-top tube, lavender-top (EDTA) tube, or green-top (heparin) tube; do not use a gel-barrier tube.
Collection Instructions
Transfer separated serum or plasma to a plastic transport tube.
Storage Instructions
Room temperature
Causes for Rejection
Gel-barrier tube (red-top tubes are recommended because gel-barrier tubes may cause significant losses (>40%) of the tricyclic antidepressant from serum)
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 14 days |
| Refrigerated | 14 days |
| Frozen | 14 days |