FIB-4 With Reflex to Enhanced Liver Fibrosis (ELF)™
Use
According to the 2022 American Association of Clinical Endocrinology clinical practice guidelines, patients considered at high risk for Nonalcoholic Fatty Liver Disease (NAFLD) should be screened for NAFLD and advanced fibrosis using the following blood-based tests:
Special Instructions
If the FIB-4 Index is greater than 1.29, testing will reflex to the Enhanced Liver Fibrosis (ELF™) test, which incurs an additional charge.
Limitations
Clumping can cause a falsely low platelet count, and platelet satellitism can lead to pseudothrombocytopenia. Fragmented blood cells might also result in falsely elevated counts. Specimens with gross hemolysis or improper labeling will be rejected.
Methodology
Immunoassay (Digital Immunoassay)
Biomarkers
LOINC Codes
- 1920-8
- 1742-6
- 777-3
- 98488-0
- 48795-9
Result Turnaround Time
3-6 days
Related Documents
For more information, please review the documents below
Specimen
Serum
Volume
2 mL divided into two tubes, 1 mL for initial testing and 1 mL for possible reflex
Minimum Volume
1.5 mL divided into two tubes, 0.75 mL for initial testing and 0.75 mL for possible reflex
Container
Gel-barrier tube or red-top tube
Collection Instructions
Separate from cells within 45 minutes of collection.
Storage Instructions
Serum sample for initial testing can be stored at room temperature. Serum sample for possible reflex can be stored refrigerated at 2°C to 8°C for 72 hours.
Causes for Rejection
Gross hemolysis; improper labeling.
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 1 day |
| Refrigerated | 3 days |
| Frozen | Unstable |