Fibrinogen Antigen
Also known as: Factor I Antigen, Fibrinogen Level
Use
Diagnosis of homozygous and heterozygous fibrinogen deficiency as well as dysfibrinogenemia; diagnosis of disseminated intravascular coagulation;1-3 fibrinogen levels can be used to assess the effectiveness of thrombolytic therapy.4
Special Instructions
Ensure that a separate frozen specimen is submitted for each test requested to prevent delays. It is important that the plasma specimen is separated from cells, transferred to a plastic transport tube, and transported frozen to avoid degradation.
Limitations
Fibrinogen is an acute-phase reactant and its levels might be elevated in conditions involving tissue damage, infection, or inflammation. Elevated levels might also be observed in smokers, during pregnancy, or in women on oral contraceptives. Conversely, diminished levels may be seen in advanced liver disease, and interference from high heparin levels, direct thrombin inhibitors, or fibrin breakdown products could falsely reduce fibrinogen levels. Assay interference may also occur due to factors like lipemia or hemolysis, potentially disrupting accurate measurements.
Methodology
Immunoassay (Immunonephelometry)
Biomarkers
LOINC Codes
- 42772-4
- 42772-4
Result Turnaround Time
3-5 days
Related Documents
For more information, please review the documents below
Specimen
Plasma
Volume
1 mL
Minimum Volume
0.5 mL
Container
Lavender-top (EDTA) tube or blue-top (sodium citrate) tube
Collection Instructions
Separate plasma from cells. Transfer specimen to a plastic transport tube and transport frozen. Avoid delays in turnaround time by submitting separate frozen specimens for each test.
Storage Instructions
Freeze. Stable frozen (-20°C) for one year if frozen within 24 hours after collection. Repeated freeze/thaw cycles are to be avoided. Alternatively, refrigerate at 2°C to 8°C for no more than eight days.
Causes for Rejection
Microbially contaminated samples; hemolysis; gross lipemia that cannot be cleared by ultracentrifugation; serum sample
Stability Requirements
| Temperature | Period |
|---|---|
| Refrigerated | no more than eight days |
| Frozen | one year if frozen within 24 hours |