Fibrinogen Antigen

Also known as: Factor I Antigen, Fibrinogen Level

Clinical Use

Use

Diagnosis of homozygous and heterozygous fibrinogen deficiency as well as dysfibrinogenemia; diagnosis of disseminated intravascular coagulation;1-3 fibrinogen levels can be used to assess the effectiveness of thrombolytic therapy.4

Special Instructions

Not provided.

Limitations

Fibrinogen is an acute-phase reactant and its levels might be elevated in conditions involving tissue damage, infection, or inflammation. Elevated levels might also be observed in smokers, during pregnancy, or in women on oral contraceptives. Conversely, diminished levels may be seen in advanced liver disease, and interference from high heparin levels, direct thrombin inhibitors, or fibrin breakdown products could falsely reduce fibrinogen levels. Assay interference may also occur due to factors like lipemia or hemolysis, potentially disrupting accurate measurements.

Test Details

Methodology

Immunoassay (Immunonephelometry)

Biomarkers

Fibrinogen Antigen

Protein

Fibrinogen

Concentration / Level • Quantitative (Continuous) (e.g., copies/mL, % expression)

LOINC Codes

Order Codes

42772-4 - Fibrinogen Ag PPP Neph-mCnc

Result Codes

42772-4 - Fibrinogen Ag PPP Neph-mCnc

Result Turnaround Time

3-5 days

Specimen

Plasma

Volume

1 mL

Minimum Volume

0.5 mL

Container

Lavender-top (EDTA) tube or blue-top (sodium citrate) tube

Collection Instructions

Separate plasma from cells. Transfer specimen to a plastic transport tube and transport frozen. Avoid delays in turnaround time by submitting separate frozen specimens for each test.

Storage Instructions

Freeze. Stable frozen (-20°C) for one year if frozen within 24 hours after collection. Repeated freeze/thaw cycles are to be avoided. Alternatively, refrigerate at 2°C to 8°C for no more than eight days.