GlycA
Use
As an (1) aid in the identification and stratification of individuals at risk for future cardiovascular (CV) disease, (2) independent marker of prognosis for recurrent cardiovascular events in patients with stable coronary disease or acute coronary syndrome, (3) aid in the assessment of disease activity and risk of CV disease in adult Rheumatoid Arthritis (RA) and psoriasis patients, when used in conjunction with standard clinical assessment and for monitoring of anti-inflammatory treatment.
Special Instructions
Ensure serum or plasma specimen is collected according to the specified procedures. Patient fasting is not necessary before the draw. Handle specimens with care to prevent hemolysis, which can reduce GlycA concentrations more than 10%. Store specimens refrigerated, and follow specific stability guidelines.
Limitations
Measurements from EDTA plasma are, on average, 3% to 5% lower than from serum samples. Measurements from NMR LipoTube specimens are, on average, 5% to 6% higher than from serum samples collected in red-top tubes. GlycA should not be interpreted without a complete clinical history. Events like tissue injury, infections, or inflammation may elevate GlycA levels. Hemolysis can significantly reduce GlycA concentrations.
Methodology
Mass Spectrometry
Biomarkers
LOINC Codes
- 82730-3
- 82730-3
Result Turnaround Time
3-6 days
Related Documents
For more information, please review the documents below
Specimen
Serum
Volume
1 mL
Minimum Volume
0.5 mL
Container
Plain red-top tube (preferred); NMR LipoTube (black-and-yellow-top tube), lavender-top (EDTA-no gel) tube or green-top (heparin-no gel) tube is acceptable
Collection Instructions
Collect specimen in plain red-top tube, clotted for 45 minutes at room temperature, centrifuge, and transfer to a transport tube for storage at 2°C to 8°C.
Patient Preparation
Patient fasting is not necessary prior to draw.
Storage Instructions
Refrigerate; stable for 14 days. Stable at room temperature for 60 hours or frozen for 24 months.
Causes for Rejection
Unspun LipoTube, unseparated plain red-top or EDTA tube, specimen drawn in gel-barrier collection tubes other than NMR LipoTube, hemolysis.
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 60 hours |
| Refrigerated | 14 days |
| Frozen | 24 months |