GM1 IgM Autoantibodies
Use
The BUHLMANN™ Anti-GM1 IgM ELISA is intended for the qualitative determination of human IgM autoantibodies directed against monosialotetrahexosylganglioside (GM1) in human serum.1
Special Instructions
This assay is not available in New York state. Separate serum from cells, transfer to a Labcorp PP transpak frozen purple tube with screw cap, and freeze immediately at ≤ -20°C until tested.
Limitations
Anti-GM1 IgM seropositivity supports but does not confirm MMN diagnosis. Seronegativity does not exclude it. IgM Anti-GM1 is also seen in other conditions such as Guillain-Barré syndrome, motor axonal neuropathy, and polyneuropathy. The test must be used with other clinical evaluations to confirm disease. It is not FDA-reviewed or approved.
Methodology
Immunoassay (ELISA)
Biomarkers
LOINC Codes
- 43241-9
- 43241-9
Result Turnaround Time
5-7 days
Related Documents
For more information, please review the documents below
Specimen
Serum
Volume
0.3 mL
Minimum Volume
0.1 mL
Container
Gel-barrier tube or red-top tube
Collection Instructions
Separate serum from cells. Transfer the serum into a Labcorp PP transpak frozen purple tube with screw cap. Freeze immediately and maintain frozen at ≤ -20°C until tested.
Patient Preparation
Lipemic samples can be avoided by having the patient fast for 12 hours prior to collection.
Storage Instructions
Freeze.
Causes for Rejection
Non-serum sample received; non-frozen serum received; grossly lipemic, hemolytic or icteric sample received
Stability Requirements
| Temperature | Period |
|---|---|
| Frozen | 4 months |