Hepatitis A Virus (HAV) Antibody, Total
Also known as: anti-HAV, Antibody to Hepatitis A Virus, HAV
Use
This assay is used to detect total antibodies (IgG and IgM) against Hepatitis A virus (HAV) and may be helpful when assessing HAV immunity. The detection of total antibodies cannot differentiate between vaccination, previously resolved infection, or active infection. If active hepatitis A infection is suspected, HAV IgM testing should be performed. Hepatitis A is a vaccine-preventable disease of the liver caused by the Hepatitis A virus (HAV). HAV is transmitted via the fecal-oral route, usually from direct person-to-person contact or consumption of contaminated food or water. Hepatitis A is an acute, self-limited disease that does not result in chronic infection. HAV IgG antibodies produced in response to vaccination and/or HAV infection persist for life and protect against reinfection.
Special Instructions
This test may exhibit interference when sample is collected from a person who is consuming a supplement with high doses of biotin (vitamin B7, B8, vitamin H, or coenzyme R). It is recommended to ask all patients who may be indicated for this test about biotin supplementation. Patients should be advised to stop biotin consumption at least 72 hours prior to sample collection.
Limitations
This assay has not been FDA cleared or approved for the screening of blood or plasma donors. Assay performance characteristics have not been established for immunocompromised or immunosuppressed individuals. This assay does not differentiate IgG and IgM. The performance characteristics of this assay have not been determined for use in cadaveric specimens.
Methodology
Immunoassay (CLIA)
Biomarkers
LOINC Codes
- 13951-9
- 13951-9
Result Turnaround Time
1-2 days
Related Documents
For more information, please review the documents below
Specimen
Serum
Volume
1 mL
Minimum Volume
0.4 mL
Container
Gel-barrier tube, red-top tube or serum transfer tube
Collection Instructions
If tube other than a gel-barrier tube is used, transfer separated serum to a screw-cap polypropylene transport tube. Do not freeze gel-barrier tube (pour off serum first).
Storage Instructions
Room temperature
Causes for Rejection
Non-EDTA plasma specimen; PST gel-barrier tube; grossly hemolyzed specimens
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 14 days |
| Refrigerated | 14 days |
| Frozen | 14 days |