HER-2/neu Immunohistochemistry (IHC), Gastric Paraffin
Also known as: c-erbB-2
Use
HER-2-positive carcinomas predict response to humanized monoclonal antibody trastuzumab (Herceptin®) in conjunction with chemotherapy in patients with advanced or metastatic gastric or gastro-esphageal junction carcinoma.
Special Instructions
Please direct any questions regarding this test to oncology customer service at 800-345-4363. Note: Fixation time and fixative used must be indicated on the test request form.
Limitations
Use of fixatives other than 10% formalin, fixation times less than six hours or greater than 48 hours may not yield reliable results.
Methodology
Immunoassay (IHC)
Biomarkers
LOINC Codes
- 18474-7
- 18474-7
- 77202-0
- 69426-5
Result Turnaround Time
2-4 days
Related Documents
For more information, please review the documents below
Specimen
Tumor Tissue (FFPE)
Volume
One paraffin block or five unstained, positively charged tissue slides cut at 4 to 5 microns and dried for one hour at 60°C.
Minimum Volume
Not provided
Container
Paraffin block transport pouch or slide mailer
Collection Instructions
FFPE tissue, preserved in 10% neutral buffered formalin, fixed for 18 to 24 hours. ASCO/CAP 2013 guidelines recommend fixation time between six and 72 hours for breast tissue; however, special ASCO/CAP guidelines have not been established for gastric cancer samples.
Storage Instructions
Maintain specimen at room temperature.
Causes for Rejection
Tumor other than gastric tumor