Hymenoptera Venom Allergy (HVA) With Components Profile
Also known as: Honey Bee, Paper Wasp, Stinging Insects, Venom, Yellow Jacket
Use
Support the diagnosis of hymenoptera venom allergy (HVA) by detection of sIgE antibodies to whole venom extracts and individual allergenic venom proteins. Identifying sIgE responses to specific molecular targets with component resolved diagnostics (CRD) helps fine-tune the diagnosis by distinguishing species-specific, co-reactive, or cross-reactive sensitizations. An accurate diagnosis, in turn, facilitates treatment, including prescription of venom immunotherapy.1
Special Instructions
Not provided.
Limitations
The prevalence of asymptomatic sensitization to hymenoptera venom poses challenges in accurately diagnosing Hymenoptera venom allergy. There is no direct correlation between venom sIgE levels and the severity of sting reactions. Patients may experience severe anaphylaxis despite low or absent specific IgE levels. Negative allergy test outcomes can occur due to several factors, such as testing during the refractory period, loss of sensitization, and systemic mastocytosis, among others.
Methodology
Immunoassay (Multiplex Protein Panel)
Biomarkers
LOINC Codes
- 8251-1 - Service Cmnt-Imp
- 6844-5 - Honey bee IgE Qn
- 60421-5 - PLA2 rApi m 1 IgE Qn
- 79167-3 - Hyaluronidase (rApi m) 2 IgE Qn
- 94275-5 - Honey bee (rApi m) 3 IgE Qn
- 94276-3 - Honey bee DPP (rApi m) 5 IgE Qn
- 82613-1 - Honey bee (rApi m) 10 IgE Qn
- 6740-5 - Yellow Jacket IgE Qn
- 66714-7 - Common wasp (rVes v) 1 IgE Qn
- 60240-9 - Common wasp (rVes v) 5 IgE Qn
- 6198-6 - Paper Wasp IgE Qn
- 63436-0 - Paper wasp (rPol d) 5 IgE Qn
- 21582-2 - Tryptase SerPl-mCnc
Result Turnaround Time
4-6 days
Related Documents
For more information, please review the documents below
Specimen
Serum
Volume
2 mL
Minimum Volume
1.0 mL
Container
Gel-barrier tube
Storage Instructions
Room temperature
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 14 days |
| Refrigerated | 14 days |
| Frozen | 3 months |
Other tests from different labs that may be relevant