Hymenoptera Venom Allergy (HVA) With Components Profile
Also known as: Honey Bee, Paper Wasp, Stinging Insects, Venom, Yellow Jacket
Use
Support the diagnosis of hymenoptera venom allergy (HVA) by detection of sIgE antibodies to whole venom extracts and individual allergenic venom proteins. Identifying sIgE responses to specific molecular targets with component resolved diagnostics (CRD) helps fine-tune the diagnosis by distinguishing species-specific, co-reactive, or cross-reactive sensitizations. An accurate diagnosis, in turn, facilitates treatment, including prescription of venom immunotherapy.1
Special Instructions
Reflex testing may incur additional CPT codes and charges. If any of the criteria for reflex testing are met, Cross-reactive Carbohydrate Determinant (CCD) IgE is performed. These include criteria related to Honey Bee Venom, Yellow Jacket Venom, and Paper Wasp Venom IgE levels and specific component negativity.
Limitations
The prevalence of asymptomatic sensitization to hymenoptera venom poses challenges in accurately diagnosing Hymenoptera venom allergy. There is no direct correlation between venom sIgE levels and the severity of sting reactions. Patients may experience severe anaphylaxis despite low or absent specific IgE levels. Negative allergy test outcomes can occur due to several factors, such as testing during the refractory period, loss of sensitization, and systemic mastocytosis, among others.
Methodology
Immunoassay (Multiplex Protein Panel)
Biomarkers
LOINC Codes
- 8251-1
- 6844-5
- 60421-5
- 79167-3
- 94275-5
- 94276-3
- 82613-1
- 6740-5
- 66714-7
- 60240-9
- 6198-6
- 63436-0
- 21582-2
Result Turnaround Time
4-6 days
Related Documents
For more information, please review the documents below
Specimen
Serum
Volume
2 mL
Minimum Volume
1.0 mL
Container
Gel-barrier tube
Storage Instructions
Room temperature
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 14 days |
| Refrigerated | 14 days |
| Frozen | 3 months |