Hymenoptera Venom Allergy (HVA) With Components Profile, II
Use
This test supports the diagnosis of hymenoptera venom allergy (HVA) by detection of sIgE antibodies to whole venom extracts and individual allergenic venom proteins. Identifying sIgE responses to specific molecular targets with component resolved diagnostics (CRD) helps fine-tune the diagnosis by distinguishing species-specific, co-reactive, or cross-reactive sensitizations. An accurate diagnosis, in turn, facilitates treatment, including prescription of venom immunotherapy.1
Special Instructions
Not provided.
Limitations
The high rate of asymptomatic sensitization to hymenoptera venom makes an accurate diagnosis of Hymenoptera venom allergy challenging. There is no correlation between the severity of sting reactions and the concentration of venom sIgE to whole venom extracts or individual components, and some patients with minimal level or absent specific IgE to these entities can develop severe anaphylaxis.
Methodology
Immunoassay (Multiplex Protein Panel)
Biomarkers
LOINC Codes
- 8251-1 - Service Cmnt-Imp
- 8251-1 - Service Cmnt-Imp
- 6056-6 - Bumble Bee IgE Qn
- 6280-2 - Whitefaced Hornet IgE Qn
- 6288-5 - Yellow Hornet IgE Qn
- 6844-5 - Honey bee IgE Qn
- 60421-5 - PLA2 rApi m 1 IgE Qn
- 79167-3 - Hyaluronidase (rApi m) 2 IgE Qn
- 94275-5 - Honey bee (rApi m) 3 IgE Qn
- 94276-3 - Honey bee DPP (rApi m) 5 IgE Qn
- 82613-1 - Honey bee (rApi m) 10 IgE Qn
- 6740-5 - Yellow Jacket IgE Qn
- 66714-7 - Common wasp (rVes v) 1 IgE Qn
- 60240-9 - Common wasp (rVes v) 5 IgE Qn
- 6198-6 - Paper Wasp IgE Qn
- 63436-0 - Paper wasp (rPol d) 5 IgE Qn
- 21582-2 - Tryptase SerPl-mCnc
Result Turnaround Time
4-6 days
Related Documents
For more information, please review the documents below
Specimen
Serum
Volume
2.5 mL
Minimum Volume
1.5 mL
Container
Gel-barrier tube
Storage Instructions
Room temperature
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 14 days |
| Refrigerated | 14 days |
| Frozen | 3 months |
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