Immunoglobulin G, Quantitative, Cerebrospinal Fluid
Also known as: Cerebrospinal Fluid IgG, CSF IgG, CSF Immunoglobulin G, IgG, CSF, IgG, Quantitative, CSF
Use
Evaluate central nervous system involvement by infection, neoplasm, or primary neurologic disease (in particular, multiple sclerosis)
Special Instructions
The third tube of a routinely obtained three-tube set of CSF should be used for the CSF IgG study.
Limitations
Normal IgG levels in CSF do not exclude disease; clinical correlation is necessary. Elevated levels of CSF protein can occur in many conditions affecting the central nervous system. A marked elevation of IgG (>16 mg/dL) occurs in some multiple sclerosis patients, whereas slightly elevated levels (11% to 16%) can overlap with non-MS conditions. During MS patient treatment with ACTH or steroid therapy, CSF IgG levels may decrease but often remain higher than normal.
Methodology
Immunoassay (Immunologic)
Biomarkers
LOINC Codes
- 2464-6
- 2464-6
Result Turnaround Time
3-5 days
Related Documents
For more information, please review the documents below
Specimen
Cerebrospinal Fluid
Volume
0.5 mL
Minimum Volume
0.25 mL
Container
Sterile container
Storage Instructions
Room temperature
Causes for Rejection
Excessive blood in CSF
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 14 days |
| Refrigerated | 14 days |
| Frozen | 14 days |