Immunoglobulins, Quantitative, IgA, IgG, IgM

Clinical Use

Use

The quantitative measurement of Immunoglobulins A, G, and M is crucial for evaluating and monitoring humoral immunity. Abnormal levels of these immunoglobulins may indicate immunodeficiency disorders, chronic infections, and autoimmune diseases. This test provides comprehensive insights into the patient's immune status, aiding in the diagnosis and management of various immune-related conditions like IgA deficiency, multiple myeloma, and hyperimmunoglobulinemia.

Special Instructions

Not provided.

Limitations

The quantitative immunoglobulin assay may not detect abnormalities in immunoglobulins that affect qualitative aspects such as functional defects. Analytical inaccuracies can arise if the sample contains paraproteins, hemolysis, or if improperly collected, stored, or handled. False results may occur in cases with extreme lipemia and interference from other proteins is possible, necessitating additional testing or confirmatory procedures.

Test Details

Methodology

Immunoassay

Biomarkers

Immunoglobulin A

Protein

Immunoglobulin A

Concentration / Level • Quantitative (Continuous) (e.g., copies/mL, % expression)

Immunoglobulin G

Protein

Immunoglobulin G

Concentration / Level • Quantitative (Continuous) (e.g., copies/mL, % expression)

Immunoglobulin M

Protein

Immunoglobulin M

Concentration / Level • Quantitative (Continuous) (e.g., copies/mL, % expression)

LOINC Codes

Order Codes

34550-4 - Immunoglobulin Pnl Ser-mCnc

Result Codes

2465-3 - IgG SerPl-mCnc
2458-8 - IgA SerPl-mCnc
2472-9 - IgM SerPl-mCnc

Result Turnaround Time

1 day

Specimen

Serum

Volume

2 mL

Minimum Volume

Not provided

Container

Red-top tube or gel-barrier tube

Storage Instructions

Samples suspected of having macroglobulins or cryoglobulins should be drawn and held at 37°C. Samples suspected of containing cold agglutinins should not be refrigerated prior to serum separation from clot.