Immunoglobulins, Quantitative, IgA, IgG, IgM
Use
The quantitative measurement of Immunoglobulins A, G, and M is crucial for evaluating and monitoring humoral immunity. Abnormal levels of these immunoglobulins may indicate immunodeficiency disorders, chronic infections, and autoimmune diseases. This test provides comprehensive insights into the patient's immune status, aiding in the diagnosis and management of various immune-related conditions like IgA deficiency, multiple myeloma, and hyperimmunoglobulinemia.
Special Instructions
State patient's age on the request form to ensure accurate interpretation of results. Ensure proper handling of specimens suspected of having macroglobulins or cryoglobulins by maintaining them at 37°C. For samples with potential cold agglutinins, avoid refrigeration before serum separation.
Limitations
The quantitative immunoglobulin assay may not detect abnormalities in immunoglobulins that affect qualitative aspects such as functional defects. Analytical inaccuracies can arise if the sample contains paraproteins, hemolysis, or if improperly collected, stored, or handled. False results may occur in cases with extreme lipemia and interference from other proteins is possible, necessitating additional testing or confirmatory procedures.
Methodology
Immunoassay
Biomarkers
LOINC Codes
- 34550-4
- 2465-3
- 2458-8
- 2472-9
Result Turnaround Time
1 day
Related Documents
For more information, please review the documents below
Specimen
Serum
Volume
2 mL
Minimum Volume
Not provided
Container
Red-top tube or gel-barrier tube
Storage Instructions
Samples suspected of having macroglobulins or cryoglobulins should be drawn and held at 37°C. Samples suspected of containing cold agglutinins should not be refrigerated prior to serum separation from clot.
Causes for Rejection
Lipemia
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 14 days |
| Refrigerated | 14 days |
| Frozen | 14 days |