Lyme Disease, Line Blot, Cerebrospinal Fluid
Use
Detects intrathecal antibody production against Borrelia burgdorferi in cerebrospinal fluid to confirm neuroborreliosis. Serves as a confirmatory immunoblot test following evidence of Lyme disease antibody presence, specifically tailored for CSF specimens.
Special Instructions
Not provided.
Limitations
This test may be considered investigational by Medicare and other payers and may not be covered. A line blot assay alone is insufficient for Lyme diagnosis; cross‑reactivity with other spirochetal diseases and autoimmune conditions is possible; interpret alongside serology and clinical presentation.
Methodology
Immunoassay (Multiplex Protein Panel)
Biomarkers
LOINC Codes
- 23979-8 - B burgdor IgG Patrn CSF IB-Imp
- 23985-5 - B burgdor IgM Patrn CSF IB-Imp
- 28054-5 - B burgdor93kD IgG CSF Ql IB
- 28039-6 - B burgdor66kD IgG CSF Ql IB
- 28048-7 - B burgdor58kD IgG CSF Ql IB
- 28055-2 - B burgdor45kD IgG CSF Ql IB
- 28040-4 - B burgdor41kD IgG CSF Ql IB
- 28036-2 - B burgdor39kD IgG CSF Ql IB
- 28053-7 - B burgdor30kD IgG CSF Ql IB
- 28056-0 - B burgdor28kD IgG CSF Ql IB
- 28057-8 - B burgdor23kD IgG CSF Ql IB
- 48500-3 - B burgdor18kD IgG CSF Ql IB
- 28043-8 - B burgdor41kD IgM CSF Ql IB
- 28037-0 - B burgdor39kD IgM CSF Ql IB
- 28062-8 - B burgdor23kD IgM CSF Ql IB
Result Turnaround Time
3-5 days
Related Documents
For more information, please review the documents below
Specimen
Cerebrospinal Fluid
Volume
2 mL
Minimum Volume
1 mL
Container
Sterile plastic tube
Collection Instructions
Maintain sterility and forward promptly. Send CSF refrigerated.
Patient Preparation
No special preparation is required.
Other tests from different labs that may be relevant