Mannose-binding Lectin (MBL)
Use
The determination of MBL concentrations in serum may be useful for the elucidation of suspected immune defects and as a prognostic indicator alerting to the need for heightened therapeutic or prophylactic measures in immunosuppressed patients, including patients receiving cancer chemotherapy and patients with cystic fibrosis, SLE, or rheumatoid arthritis.
Special Instructions
No special patient preparations are necessary. If a red-top tube is used, transfer separated serum to a plastic transport tube.
Limitations
This test was developed and its performance characteristics determined by Labcorp. It has not been cleared or approved by the Food and Drug Administration. Diminished MBL levels can occur due to allelic variants in the promoter and/or structural regions of the MBL gene. Only normally oligomerized forms of MBL can efficiently bind to microbial carbohydrates and associate with MASPs.
Methodology
Immunoassay (ELISA)
Biomarkers
LOINC Codes
- 30152-3
Result Turnaround Time
5-7 days
Related Documents
For more information, please review the documents below
Specimen
Serum
Volume
0.5 mL
Minimum Volume
0.1 mL
Container
Gel-barrier tube or red-top tube
Collection Instructions
If a red-top tube is used, transfer separated serum to a plastic transport tube.
Storage Instructions
Maintain specimen at room temperature. Stable 14 days. Stable refrigerated or frozen for 14 days. Freeze/thaw cycles: stable x3.
Causes for Rejection
Nonserum sample; hemolyzed or hyperlipemic sample received
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 14 days |
| Refrigerated | 14 days |
| Frozen | 14 days |