Mitotane, Serum or Plasma
Also known as: Lysodren®
Use
Therapeutic drug management
Special Instructions
Serum or plasma samples need to be separated from cells within two hours of venipuncture and transferred to a plastic transport tube. This step is critical to prevent any alteration in the sample integrity that could affect test accuracy. Gel-barrier tubes are not acceptable, indicating the necessity for strict adherence to the specified tube types for collection.
Limitations
The test relies on gas chromatography/flame ionization detection which is precise for measuring mitotane levels; however, it may not detect metabolites. Volatile compounds or improper sample handling, such as using gel-barrier tubes, could lead to inaccurate results. The minimum volume of 0.5 mL is crucial for test processing, and insufficient volume could result in rejection or delayed processing.
Methodology
Mass Spectrometry
Biomarkers
LOINC Codes
- 13626-7
- 13626-7
Result Turnaround Time
7-10 days
Related Documents
For more information, please review the documents below
Specimen
Serum
Volume
2 mL
Minimum Volume
0.5 mL
Container
Red-top tube or green-top (heparin) tube. Gel-barrier tubes are not acceptable.
Collection Instructions
Serum or plasma should be separated from cells within two hours of venipuncture. Submit serum or plasma in a plastic transport tube.
Patient Preparation
Trough levels are most reproducible.
Storage Instructions
Submission/transport (<3 days): Room temperature. For storage beyond three days, specimen should be refrigerated or frozen.
Causes for Rejection
Gel-barrier tubes