Mononucleosis Test, Qualitative
Also known as: Infectious Mononucleosis Antibodies
Use
Detect heterophil antibodies related to infectious mononucleosis
Special Instructions
A positive test result, when found alongside clinical symptoms and hematologic findings, strongly supports a diagnosis of infectious mononucleosis. Attention should be given to false-positive results, which can cause diagnostic confusion. Approximately 10% of mononucleosis cases are heterophil-negative, necessitating further testing for Epstein-Barr virus or other related conditions such as CMV, HSV, or Toxoplasmosis.
Limitations
This qualitative test has excellent specificity; however, false positives may occur, leading to potential diagnostic confusion. Rarely, patients may test positive for heterophil agglutinins after initially testing negative. Up to 10% of true Epstein-Barr virus mononucleosis cases may yield a negative result on this test. These specific cases can be diagnosed using EBV-specific tests. The sensitivity of this test is 80-90%, while Epstein Barr IgM testing provides higher sensitivity.
Methodology
Other
Biomarkers
LOINC Codes
- 5213-4
- 5213-4
Result Turnaround Time
1-2 days
Related Documents
For more information, please review the documents below
Specimen
Serum
Volume
1 mL
Minimum Volume
0.5 mL
Container
Red-top tube or gel-barrier tube
Storage Instructions
Maintain specimen at room temperature.
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 14 days |
| Refrigerated | 14 days |
| Frozen | 14 days |