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Primary infection by EBV causes infectious mononucleosis, usually a self‑limiting disease in children and young adults. Infection with EBV can cause lymphoproliferative disorders including tumors. VCA‑IgM is typically detectable at clinical presentation, then declines to undetectable levels within a month in young children and within 3 months in other individuals. VCA‑IgG is typically detectable at clinical presentation and persists for life. EBNA IgG typically appears during convalescence (3‑4 months after clinical presentation) and remains detectable for life.