Myasthenia Gravis Profile
Use
Tests for the laboratory diagnosis of myasthenia gravis (MG)
Special Instructions
This assay is not available in New York state. Patients should ensure no isotopes are administered 24 hours prior to venipuncture. Serum samples must be separated within two hours of collection.
Limitations
AChR antibodies can rarely be found in patients with other autoimmune disorders or thymoma without MG. Up to 15% of MG patients do not have identifiable AChR antibodies. Striational antibodies are associated with late-onset MG and are rare in AChR antibody-negative MG. Autoantibody levels may not correlate with disease severity, though serial antibody titers can indicate disease status in individual patients.
Methodology
Immunoassay (Multiplex Protein Panel)
Biomarkers
LOINC Codes
- 55397-4
- 11034-6
- 11561-8
- 99062-2
- 5372-8
Result Turnaround Time
6-8 days
Related Documents
For more information, please review the documents below
Specimen
Serum
Volume
4 mL divided into two tubes
Minimum Volume
2 mL
Container
Red-top tube or gel-barrier tube
Collection Instructions
Allow a minimum clotting time of 30 to 60 minutes with serum separation within 2 hours of collection. Send serum samples in plastic transport tubes.
Patient Preparation
No isotopes administered 24 hours prior to venipuncture.
Storage Instructions
Refrigerate.
Causes for Rejection
Excessive hemolysis; chylous serum; recently administered radioisotopes; plasma specimen
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 7 days |
| Refrigerated | 14 days |
| Frozen | 14 days |