Myelodysplastic Syndrome (MDS), FISH
Use
Diagnostic test for myelodysplastic syndrome. The principal use is for interphase analysis of cases with no (or low) mitotic activity in cytogenetic analysis or interphase analysis from blood in cases of inaspirable bone marrow. Detection rate is approximately 80% of clones detected in cytogenetic analysis.
Special Instructions
Indicate pertinent clinical diagnosis and previous cytogenetic studies on the test request form. Utilize sterile technique and Labcorp transport kits for specimen collection when possible.
Limitations
This test is limited to detecting chromosomal abnormalities targeted by the specific DNA probes included in the study. Molecular mutations or chromosomal alterations not targeted by these probes will not be detected. Results should be interpreted in conjunction with a full cytogenetic analysis and hematologic evaluation. It is important to note that the test has not been cleared or approved by the FDA, but the FDA has determined that such clearance or approval is not necessary.
Methodology
Chromosomal / Cytogenetics (FISH)
Biomarkers
LOINC Codes
- 31208-2
- 48672-0
- 50398-7
- 57802-1
- 62360-3
- 62361-1
- 62361-1
- 62360-3
- 57802-1
- 50398-7
- 31208-2
- 48672-0
Result Turnaround Time
3-5 days
Related Documents
For more information, please review the documents below
Specimen
Whole Blood
Volume
5 mL
Minimum Volume
1 mL
Container
Green-top (sodium heparin) tube; pediatric Vacutainer® is optimal or lavender-top (EDTA) tube (suboptimal)
Collection Instructions
Utilize sterile technique and Labcorp transport kits when possible.
Storage Instructions
Transport to the testing laboratory at room temperature; use of a cool pack or a Labcorp transport kit is acceptable. Do not allow samples to overheat or freeze.
Causes for Rejection
Broken Vacutainer®; broken or stained slides; decalcified bone core; frozen specimen; quantity not sufficient for analysis