Neuron-specific Enolase (NSE)
Use
An aid in the detection and monitoring of neuroendocrine tumors (NETs), particularly those associated with small-cell lung cancer (SCLC)
Special Instructions
Not provided.
Limitations
The test was developed and its performance characteristics determined by Labcorp, but it hasn't been cleared or approved by the FDA. Hemolysis can falsely elevate NSE levels due to erythrocytes' high NSE content. Variability across different assay methods limits result interchangeability. The test's specificity and sensitivity are influenced by the method used, for instance, the Brahms Kryptor assay displays specific sensitivity thresholds for distinguishing between various types of lung cancer.
Methodology
Immunoassay (Other)
Biomarkers
Neuron-specific enolase
Protein
LOINC Codes
- 57371-7 - NSE SerPl IA-mCnc
- 57371-7 - NSE SerPl IA-mCnc
Result Turnaround Time
3-10 days
Related Documents
For more information, please review the documents below
Specimen
Serum
Volume
0.5 mL
Minimum Volume
0.3 mL
Container
Red-top tube or gel-barrier tube
Collection Instructions
Transfer separated serum to a plastic transport tube as quickly as possible after the clot has formed (within 30 minutes of collection).
Storage Instructions
Refrigerate.
Causes for Rejection
Hemolysis; gross icterus; plasma specimen
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 7 days |
| Refrigerated | 7 days |
| Frozen | 14 days |
Other tests from different labs that may be relevant