Pediatric Acute Lymphoblastic Leukemia (ALL) Profile, FISH
Also known as: Acute Lymphocytic Leukemia (ALL), Pediatric
Use
Diagnostic and prognostic test for acute lymphoblastic leukemia in the pediatric population; detection rate is improved from 50% with a chromosome study to 90% with FISH
Special Instructions
It is vital to indicate the clinical diagnosis and any previous cytogenetic studies on the test request form. Use sterile techniques and Labcorp transport kits for specimen collection.
Limitations
The test can detect only those molecular mutations or chromosomal alterations directly targeted by the included probes. It cannot detect alterations outside these targeted areas, highlighting the importance of integrating these results with a full cytogenetic analysis and clinical evaluation for comprehensive patient assessment.
Methodology
Chromosomal / Cytogenetics (FISH)
Biomarkers
LOINC Codes
- 31208-2
- 62361-1
- 62360-3
- 48674-6
- 50398-7
- 48672-0
- 11502-2
Result Turnaround Time
3-5 days
Related Documents
For more information, please review the documents below
Specimen
Whole Blood
Volume
5 mL
Minimum Volume
1 mL
Container
Green-top (sodium heparin) tube; pediatric Vacutainer® is optimal or lavender-top (EDTA) tube (suboptimal)
Collection Instructions
Utilize sterile technique and Labcorp transport kits when possible.
Storage Instructions
Transport to the testing laboratory at room temperature; use of a cool pack or a Labcorp transport kit is acceptable. Do not allow samples to overheat or freeze.
Causes for Rejection
Broken Vacutainer®; broken or stained slides; paraffin blocks; paraffin slides; decalcified bone cores; frozen specimen; quantity not sufficient for analysis