Pregnancy, Infectious Disease Antibody Profile (CMV, Parvovirus, Toxoplasma)
Also known as: CMV, Parvovirus, Torch, Toxoplasmosis
Use
CMV: Routine screening of pregnant people for CMV is not recommended by current guidelines. Maternal CMV IgM antibody has limited clinical utility in differentiating primary from recurrent infection. An IgG-positive, IgM-negative result typically indicates past infection; however, IgG avidity testing, to determine the time since primary infection, should be considered if clinically warranted. An IgG-positive, IgM-positive result suggests recent primary infection and IgG avidity testing is recommended to determine the time since primary infection. An IgG-negative, IgM-positive result suggests very recent infection and the patient should be followed to document seroconversion. An IgG-negative, IgM-negative result indicates susceptibility to infection.
Special Instructions
Routine screening for CMV, Parvovirus B19, and Toxoplasma in pregnancy is not generally recommended by current guidelines unless specific symptoms or exposure to these infections occur. CMV IgM has limited clinical utility, with IgG avidity testing suggested to determine the primary infection time. Special handling involves transporting serum in plastic tubes when not using gel barrier tubes. Use plastic transport tubes for freezing, avoiding freezing of gel-barrier tubes.
Limitations
The assays included in this profile are not approved for screening blood/plasma donations. Limitations include possible prolonged presence of Toxoplasma IgM for months or years post-infection and potential for false-positive results. It's also critical to follow guidelines for IgG and IgM interpretations to avoid incorrect clinical decisions.
Methodology
Immunoassay
Biomarkers
LOINC Codes
- 13949-3
- 24119-0
- 5388-4
- 5390-0
- 5273-8
- 5274-6
Result Turnaround Time
2-3 days
Related Documents
For more information, please review the documents below
Specimen
Serum
Volume
2.0 mL
Minimum Volume
1.0 mL
Container
Gel barrier tube or red-top tube or serum transfer tube
Collection Instructions
If tube other than a gel barrier tube is used, transfer separated serum to a plastic transport tube. Do not freeze gel-barrier tubes; transfer serum to a plastic transport tube prior to freezing.
Storage Instructions
Room temperature
Causes for Rejection
Hemolysis; lipemia; gross bacterial contamination
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 14 days |
| Refrigerated | 14 days |
| Frozen | 14 days |