PrEP Use Only: HBV Screening and Diagnosis (Triple Panel)

Also known as: Pre-exposure prophylaxis screening for hepatitis B virus

Clinical Use

Use

This test is used for HBV screening and diagnosis in patients administered HIV PrEP. This is a triple test panel intended for screening and diagnosis of hepatitis B virus (HBV) infection. This panel can be used to identify different phases of HBV infection and to determine whether a patient has acute or chronic HBV as a result of prior infection or vaccination or is susceptible to infection. This panel aligns with current CDC recommendations for HBV screening and testing.

Special Instructions

Not provided.

Limitations

The assays included in this panel have not been validated with cadaveric specimens, heat-inactivated specimens, or body fluids other than serum and EDTA plasma. There may be interference when samples are collected from individuals consuming biotin supplements. The test may not be valid in specimens outside the specified collection criteria.

Test Details

Methodology

Immunoassay (ECLIA)

Biomarkers

4 targets

Hepatitis B Core Antibody, IgM (IgM anti-HBc)Hepatitis B Core Antibody, Total (anti-HBc)Hepatitis B Surface Antibody (anti-HBs)Hepatitis B Surface Antigen (HBsAg)

LOINC Codes

Order Codes

77190-7 - HBV core + surf Ab + surf Ag Pnl Ser

Result Codes

5196-1 - HBV surface Ag SerPl Ql IA
22322-2 - HBV surface Ab Ser Ql
13952-7 - HBV core Ab SerPl Ql IA
77202-0 - Laboratory comment Report
56850-1 - Imp & review of lab results

Result Turnaround Time

1-2 days

Specimen

Serum

Volume

5 mL

Minimum Volume

2.5 mL

Container

Gel-barrier tube, red-top tube or serum transfer tube

Collection Instructions

If a tube other than a gel-barrier tube is used, transfer separated serum to a screw-cap polypropylene transport tube. Do not freeze gel-barrier tube (pour off serum first).