Prostate-specific Antigen (PSA), Complexed
Also known as: PSA, Complexed
Use
PSA is a single-chain glycoprotein normally found in the cytoplasm of the epithelial cells lining the acini and ducts of the prostate gland.1,2 PSA is a neutral serine protease of 240 amino acids involved in the lysis of seminal coagulum.1,3,4 PSA is present in the serum of males with normal, benign hyperplastic and malignant prostate tissue. PSA exists predominantly in circulation in complexes with various protease inhibitors. The most prevalent form of complexed cPSA that can be detected is bound to α1-antichymotrypsin.1,5
Special Instructions
Not provided.
Limitations
Serum cPSA measurement is not an absolute test for malignancy. The cPSA value should be used in conjunction with information available from clinical evaluation and other diagnostic procedures. Some cases of benign prostatic hypertrophy and prostatitis show elevation of cPSA, but such increases are below those found with prostate adenocarcinoma stages C and D. Elevations may also be associated with urethral instrumentation, TUR, prostatic needle biopsy, urinary retention, or prostatic infarct. Values obtained with different assay methods or kits cannot be used interchangeably.
Methodology
Immunoassay (CLIA)
Biomarkers
PSA, Complexed
Protein
LOINC Codes
- 33667-7 - Complexed PSA SerPl-mCnc
- 33667-7 - Complexed PSA SerPl-mCnc
Result Turnaround Time
2-4 days
Related Documents
For more information, please review the documents below
Specimen
Serum
Volume
0.5 mL
Minimum Volume
Not provided
Container
Red-top tube or gel-barrier tube
Collection Instructions
If a red-top tube is used, transfer separated serum to a plastic transport tube.
Storage Instructions
Maintain specimen at room temperature.
Causes for Rejection
Plasma or whole blood specimen; hemolysis
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 14 days |
| Refrigerated | 14 days |
| Frozen | 14 days |
Other tests from different labs that may be relevant