Prostate-specific Antigen (PSA), Ultrasensitive

Casandra

Casandra Test Code LC97873Version 1 (DRAFT)

Performing Lab

Lab LabcorpLab Test ID 140731CPT Code 84153

Prostate-specific Antigen (PSA), Ultrasensitive

Also known as: PSA, Third Generation

Clinical Use

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Use

Prostate-specific antigen (PSA) is a glycoprotein produced by the epithelial cells lining the prostatic ducts and acini. Normally, it is secreted into the prostatic ducts and is present only in prostate tissue, prostatic fluid, and seminal plasma. PSA is produced by normal, hyperplastic, and cancerous prostatic tissue. PSA is used as a tumor marker for the early detection of prostate cancer and in other areas of prostate disease management.1 The Prostate-Specific Antigen Best Practice Statement: 2009 Update1 published by the American Urologic Association describes the use of PSA testing for:

Special Instructions

PSA sampling should not be performed for six weeks post-prostatic biopsy. This procedure is intended for one-time use, with serial monitoring requiring a different test number (140723). Values from different methods should not be used interchangeably, and consistent assay methods should be used for patient monitoring.

Limitations

PSA values can vary significantly depending on the testing procedure used, leading to potential false interpretations if different procedures are mixed. Results should not be solely trusted as definitive evidence of malignant disease presence or absence. PSA levels may be elevated due to non-cancerous factors such as prostatitis, benign prostatic hyperplasia, trauma, or certain medical interventions. Drugs like Finasteride and dutasteride can lower PSA levels by 50%. Prostate biopsy significantly elevates PSA levels, but variations from digital rectal exams or ejaculation are inconsistent.

Test Details