Protein and Creatinine, Random Urine
Use
Protein:creatinine ratio in a first-morning or random untimed "spot" urine specimen is recommended testing to ascertain chronic kidney disease.1 It is also used to evaluate nephrotic syndromes; work up other renal diseases, including malignant hypertension, glomerulonephritis, Goodpasture syndrome, cryoglobulinemia, toxemia of pregnancy, drug nephrotoxicity, and renal tubular lesions; manage myeloma and macroglobulinemia of Waldenström (Bence Jones proteinuria); evaluate hypoproteinemia; tubular proteinurias, including Wilson's disease and Fanconi syndrome. Albumin/Creatinine Ratio, Random Urine is a more sensitive marker of progression and regression of renal disease than urine total protein, especially when urine total protein is <300 mg/g creatinine.
Special Instructions
Label the urine container with the patient's full name and the date and time of collection.
Limitations
The test uses a random urine sample, and factors such as hydration can influence creatinine levels in urine, potentially affecting the accuracy of protein:creatinine ratio. It may require additional confirmatory testing or clinical correlation with other diagnostic methods for comprehensive evaluation, especially in complex renal conditions.
Methodology
Automated Analyzer (Clinical Chemistry)
Biomarkers
LOINC Codes
- 87434-7
- 2161-8
- 2888-6
- 2890-2
Result Turnaround Time
1 day
Related Documents
For more information, please review the documents below
Specimen
Urine
Volume
50 mL
Minimum Volume
1 mL
Container
Plastic urine container, no preservative
Collection Instructions
Collect random urine in a clean plastic container. Label the urine container with the patient's full name and the date and time of collection.
Storage Instructions
Room temperature
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 7 days |
| Refrigerated | 14 days |
| Frozen | 14 days |