SARS-CoV-2 Antibody Profile, Nucleocapsid and Spike

Casandra

Casandra Test Code LC87420Version 1 (DRAFT)

Performing Lab

Lab LabcorpLab Test ID 160236CPT Code 86769

SARS-CoV-2 Antibody Profile, Nucleocapsid and Spike

Also known as: SARS-CoV-2

Clinical Use

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Use

To evaluate for evidence of previous SARS-CoV-2 infection in individuals with a history of COVID-19 vaccination to aide in the diagnosis of Multisystem Inflammatory Syndrome in children (MIS-C) or adults (MIS-A). The presence of antibodies specific to the SARS-CoV-2 viral nucleocapsid protein is consistent with natural infection as currently available COVID-19 vaccines induce antibodies against the viral spike protein receptor binding domain (RBD) only.

Special Instructions

Not provided.

Limitations

These tests should not be used to diagnose or exclude acute SARS-CoV-2 infection. Results should be assessed alongside patient's medical history and other clinical findings. Negative results do not rule out the possibility of SARS-CoV-2 infection, especially in pre-seroconversion phases. Some patients may not develop antibodies even after confirmed infection. Antibody titers may wane within months post-infection. The test is authorized under FDA EUA but not cleared or fully approved. It is authorized for detecting antibodies against SARS-CoV-2 only, not for other pathogens.

Test Details