VistaSeq® MSH2 Comprehensive Analysis
Also known as: Familial Cancer testing, Hereditary Cancer testing, Inherited Cancer testing
Use
This assay is intended for patients with a personal or family history consistent with MSH2-related Lynch syndrome.
Special Instructions
Not provided.
Limitations
The test may not detect noncoding or deep intronic variants, mosaic variants, certain genomic rearrangements, or exact breakpoints of deletions/duplications. It is not intended for identifying somatic variants or for use in bone marrow transplantation context. The presence of pseudogenes like PMS2CL could interfere with variant detection in related genes. Comprehensive diagnosis may require correlation with other clinical information and tests.
Methodology
NGS (Targeted)
Biomarkers
MSH2
Gene
LOINC Codes
- 41084-5 - MSH2 gene Mut Anl Bld/T
- 31208-2 - Specimen source
- 41084-5 - MSH2 gene Mut Anl Bld/T
- 56850-1 - Imp & review of lab results
- 62385-0 - Recommendation Patient Doc-Imp
- 55752-0 - Clinical info
- 49549-9 - Ref lab test method
- 75608-0 - Citation Ref Lab Test
- 72486-4 - Lab director name Provider
- 51969-4 - Gene analysis narr rpt Doc
Result Turnaround Time
20-28 days
Related Documents
For more information, please review the documents below
Specimen
Whole Blood
Volume
10 mL
Minimum Volume
7 mL
Container
Lavender-top (EDTA) tube or yellow-top (ACD) tube
Collection Instructions
Blood is collected by routine phlebotomy.
Storage Instructions
Room temperature or refrigerated
Causes for Rejection
Frozen specimen; leaking tube; clotted specimen; grossly or hemolyzed specimen; quantity not sufficient for analysis; incorrect anticoagulant.
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 60 days |
| Refrigerated | 60 days |
| Frozen | N/A |
Other tests from different labs that may be relevant