West Nile Virus (WNV) Antibody, IgG and IgM, CSF
Also known as: Flavivirus, Mosquito-borne, Vectorborne, West Nile Virus, IgG and IgM, West Nile Virus, Serology
Use
This test is indicated for use as an aid to the diagnosis of West Nile virus encephalitis. WNV IgM antibodies typically appear three to eight days after illness onset and persist 30 to 90 days (but can persist up to 500 days). WNV IgG antibodies appear shortly after IgM antibodies and persist greater than 500 days. Due to cross-reactivity with other flaviviruses, confirmation by neutralizing antibody assay may be recommended.
Special Instructions
Not provided.
Limitations
The performance of this assay has not been established for screening the general population. Testing should only be performed on patients with clinical symptoms consistent with WNV encephalitis. Serological cross-reactivity across the flavivirus group is common, which includes Dengue virus, Japanese encephalitis virus, St. Louis encephalitis virus, yellow fever virus, and others.
Methodology
Immunoassay (ELISA)
Biomarkers
West Nile Virus, IgG
MicroorganismWest Nile Virus, IgM
Microorganism
LOINC Codes
- 94853-9 - WNV IgG+IgM Pnl CSF
- 41236-1 - WNV IgG CSF Ql
- 31703-2 - WNV IgM CSF Ql
Result Turnaround Time
1-4 days
Related Documents
For more information, please review the documents below
Specimen
Cerebrospinal Fluid
Volume
0.5 mL
Minimum Volume
0.2 mL
Container
Sterile container
Collection Instructions
Do not centrifuge cerebrospinal fluid.
Storage Instructions
Room temperature
Causes for Rejection
Gross contamination; severe hemolysis; quantity not sufficient for analysis
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 14 days |
| Refrigerated | 14 days |
| Frozen | 14 days |
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