1,3-Beta-D-Glucan (Fungitell), Serum
Use
The 1,3-Beta-D-Glucan (Fungitell) test aids in diagnosing invasive fungal infections caused by various fungi, including Aspergillus species, Fusarium species, Candida species, and Pneumocystis jirovecii. It is especially useful for patients at risk for such infections, like those with hematologic or immune deficiencies, transplant recipients, and patients undergoing hemodialysis. The test detects circulating (1,3)-beta-D-glucan in serum, which is a component of the cell walls of many fungi. The presence of elevated levels of this biomarker suggests an active fungal infection.
Special Instructions
Avoid exposure of the specimen to the atmosphere to prevent environmental contamination. Centrifuge and send the entire specimen in the original collection tube without aliquoting or opening the tube. If not ordering electronically, print and send one of the following forms with the specimen: General Request (T239), Microbiology Test Request (T244), or Kidney Transplant Test Request. The assay should be used alongside other diagnostic tests, including cultures, histologic examinations, and radiologic findings.
Limitations
The BDG assay does not detect fungi such as Cryptococcus species, Blastomyces species, and Mucorales, which do not produce (1,3)-beta-D-glucan. False-positive results may occur following recent hemodialysis, use of certain blood products, or exposure to glucan-containing gauze. Single time-point testing is less reliable than serial testing, which is recommended to improve diagnostic accuracy and monitor disease progression. The BDG assay does not identify specific fungal organisms. Diagnosis should be performed in conjunction with other clinical evaluations and tests.
FDA ApprovedNew York Approved
Methodology
Immunoassay (Colorimetric Assay)
Biomarkers
LOINC Codes
- 42176-8
- 42176-8
- 93812-6
Result Turnaround Time
1-2 days
Related Documents
For more information, please review the documents below
Specimen
Serum
Volume
1 mL
Minimum Volume
0.5 mL
Container
Serum gel tube
Collection Instructions
Avoid exposure to atmosphere. Centrifuge and send entire specimen in the original collection tube. Do not aliquot or open tube.
Causes for Rejection
Gross hemolysis, gross lipemia, gross icterus, finger/heel sticks
Stability Requirements
| Temperature | Period |
|---|---|
| Refrigerated | 14 days |
| Frozen | 30 days |