Adenylate Kinase Enzyme Activity, Blood
Use
This test is useful for the evaluation of chronic nonspherocytic hemolytic anemia. Adenylate kinase (AK) deficiency is a rare autosomal recessive condition that causes nonspherocytic hemolytic anemia. Individuals with heterozygous genetic alterations are usually asymptomatic, while those with homozygous or compound heterozygous mutations can present with significant anemia, hyperbilirubinemia, and gallstones. The test measures the enzyme activity to aid in diagnosing AK deficiency, which is one reason for hemolytic anemia.
Special Instructions
Not provided.
Limitations
Recent blood transfusions may obscure the results by affecting the patient's intrinsic enzyme levels, leading to unreliable outcomes. Additionally, this test may not detect carrier states effectively, as carriers may show only mildly decreased or normal enzyme activity. Other red blood cell enzyme activities in a panel may be used for comparative analysis and should be considered in conjunction to provide a complete assessment.
New York Approved
Methodology
Automated Analyzer (Clinical Chemistry)
Biomarkers
Adenylate Kinase
Analyte
LOINC Codes
- 44051-1 - Adenylate kinase RBC-cCnt
- 44051-1 - Adenylate kinase RBC-cCnt
Result Turnaround Time
1-6 days
Related Documents
For more information, please review the documents below
Specimen
Whole Blood
Volume
6 mL
Minimum Volume
1 mL
Container
Yellow top (ACD solution B); Lavender top (EDTA) or yellow top (ACD solution A) accepted
Collection Instructions
Invert several times to mix blood. Send whole blood specimen in original tube. Do not aliquot.
Causes for Rejection
Gross hemolysis, Fully clotted
Stability Requirements
| Temperature | Period |
|---|---|
| Refrigerated | 20 days |