Alpha-1-Microglobulin, Random, Urine
Use
Measurement of urinary alpha‑1‑microglobulin (a low‑molecular‑weight protein filtered by glomeruli and reabsorbed in proximal tubules) helps assess renal proximal tubular injury or dysfunction. Elevations may indicate tubular damage from nephropathies, toxins, drug exposure, or pyelonephritis. A random urine sample is used, and results adjusted by urinary creatinine to account for dilution. ([mayocliniclabs.com](https://www.mayocliniclabs.com/test-catalog/overview/610364?utm_source=openai))
Special Instructions
If not ordered electronically, a Renal Diagnostics Test Request (T830) form must be printed and sent with the specimen. ([mayocliniclabs.com](https://www.mayocliniclabs.com/test-catalog/overview/610364?utm_source=openai))
Limitations
Turbid or particulate urine specimens (e.g., containing cells or crystals) may interfere with nephelometric assay; centrifugation at ambient temperature prior to analysis is recommended. ([mayocliniclabs.com](https://www.mayocliniclabs.com/test-catalog/overview/610364?utm_source=openai))
New York Approved
Methodology
Immunoassay (Nephelometry)
Biomarkers
LOINC Codes
- 48415-4
- 46723-3
- 48415-4
- 2161-8
Result Turnaround Time
1-4 days
Related Documents
For more information, please review the documents below
Specimen
Urine
Volume
5 mL
Minimum Volume
1 mL
Container
Plastic, 5-mL tube
Collection Instructions
Collect a random urine specimen. No preservative.
Causes for Rejection
All specimens will be evaluated at Mayo Clinic Laboratories for test suitability.
Stability Requirements
| Temperature | Period |
|---|---|
| Refrigerated | 7 days |
| Frozen | 7 days |