Amino Acids, Quantitative, Plasma
Use
Evaluating patients with possible inborn errors of metabolism using plasma specimens. May aid in evaluation of endocrine disorders, liver diseases, muscle diseases, neoplastic diseases, neurological disorders, nutritional disturbances, kidney failure, and burns. Monitoring of patients treated for various inborn errors of metabolism or other causes of amino acid imbalances.
Special Instructions
Patient's age is required. Include family history, clinical condition, diet, and drug therapy information. Fasting: 4 hours, required; infants should have specimen collected before next feeding.
Limitations
Reference values are for fasting patients. Patients with phenylketonuria (PKU) who are treated with pegvaliase-pqpz (Palynziq) may have false low phenylalanine concentrations due to persistent activity in collected blood specimens. This assay does not measure total homocysteine. If relevant disorders are considered, also order CMMPP / Cobalamin, Methionine, and Methylmalonic Acid Pathways, Plasma or HCYSP / Homocysteine, Total, Plasma analysis.
New York Approved
Methodology
Mass Spectrometry (LC-MS/MS)
Biomarkers
LOINC Codes
- 35083-5
- 20657-3
- 20638-3
- 20656-5
- 20644-1
- 20643-3
- 20645-8
- 20658-1
- 20640-9
- 26604-9
- 20636-7
- 20642-5
- 32227-1
- 20637-5
- 20634-2
- 20655-7
- 20652-4
- 22672-0
- 20650-8
- 20651-6
- 20661-5
- 20660-7
- 20648-2
- 20649-0
- 14875-9
- 49247-0
- 22670-4
- 26600-7
- 26607-2
- 26605-6
- 20633-4
- 20635-9
- 55876-7
- 20647-4
- 20639-1
- 26608-0
- 26613-0
- 26609-8
- 26610-6
- 20659-9
Result Turnaround Time
3-5 days
Related Documents
For more information, please review the documents below
Specimen
Plasma
Volume
0.5 mL
Minimum Volume
0.3 mL
Container
Plastic vial
Collection Instructions
Collect specimen and place on wet ice. Centrifuge immediately or within 4 hours of collection if the specimen is kept at refrigerated temperature. Aliquot plasma into a plastic vial and freeze.
Patient Preparation
Fasting: 4 hours, required; infants should have specimen collected before next feeding.
Causes for Rejection
Thrombin-activated tubes should not be used for collection.
Stability Requirements
| Temperature | Period |
|---|---|
| Frozen | 14 days |