Amyloid A (Hepatic) Immunostain, Technical Component Only
Use
Amyloid A (AA), also known as serum AA, is an acute-phase protein. In the liver, AA is expressed on hepatocytes, with expression also observed in adipocytes. It helps in differentiating hepatic adenomas using a panel of immunohistochemical markers such as beta-catenin, liver fatty acid-binding protein, C-reactive protein, and glutamine synthetase. AA and C-reactive protein are overexpressed in inflammatory hepatic adenomas (type 3), but are not detectable in normal liver or other adenoma types. This test aids in the classification of hepatic adenomas.
Special Instructions
Not provided.
Limitations
This test is not useful for amyloid typing. Interpretation must be performed by a qualified pathologist in the context of the patient's clinical history and other diagnostic tests. The age and charge of glass slides can affect immunoreactivity, with variation in antigen stability thresholds across literature. It is advised to cut paraffin sections within six weeks.
FDA ApprovedNew York Approved
Methodology
Immunoassay (IHC)
Biomarkers
Amyloid A
Protein
LOINC Codes
- Order only;no result
Result Turnaround Time
1-3 days
Related Documents
For more information, please review the documents below
Specimen
Tissue (FFPE)
Volume
Not provided
Minimum Volume
Not provided
Container
Immunostain Technical Only Envelope
Causes for Rejection
Wet/frozen tissue, Cytology smears, Nonformalin fixed tissue, Nonparaffin embedded tissue, Noncharged slides, ProbeOn slides, Snowcoat slides
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | Ambient (preferred) |