Use

Amyloidosis is a hereditary and acquired diseases group characterized by extracellular deposition of misfolded proteins leading to end organ damage. Specific amyloid-related diseases are associated with specific amyloid proteins, such as kappa or lambda immunoglobulin light chains (AL amyloid), transthyretin (ATTR amyloid), and serum amyloid A (SAA amyloid). Accurate protein identification is crucial since treatment varies based on amyloid subtype. This test employs Congo red staining followed by laser microdissection and mass spectrometry to reliably determine the identity of proteins constituting the amyloid.