Anaplasma phagocytophilum (Human Granulocytic Ehrlichiosis) Antibody, Serum

Casandra

Casandra Test Code MC74193Version 1 (DRAFT)

Performing Lab

Lab Mayo Clinic LabLab Test ID ANAPCPT Code 86666

Anaplasma phagocytophilum (Human Granulocytic Ehrlichiosis) Antibody, Serum

Clinical Use

Use

This test is useful as an adjunct in the diagnosis of human granulocytic ehrlichiosis (anaplasmosis) and for conducting seroepidemiological surveys to determine the prevalence of the infection in specific populations. Anaplasma phagocytophilum is an intracellular bacterium transmitted by Ixodes species ticks, causing human granulocytic anaplasmosis (HGA). Symptoms in healthy individuals are generally mild, including fever, myalgia, arthralgia, and nausea. It's prevalent in areas endemic for Lyme disease like the upper Midwest of the United States.

Special Instructions

For optimal test performance, centrifuge and aliquot serum into a plastic vial using a serum gel or red top collection tube. If not ordering electronically, complete and send the Infectious Disease Serology Test Request form with the specimen. The test is performed Monday through Friday and results are usually available within 1 to 3 days.

Limitations

Performance characteristics have not been established for hemolyzed or lipemic specimens. In rare instances, direct microscopic examination of stained peripheral blood buffy coat smears may reveal morulae but is a very insensitive diagnostic method. Previous episodes of the disease may produce a positive serologic result, which should be considered when interpreting results. Additionally, serologic tests are often nonreactive during the acute phase, necessitating PCR testing for diagnosis in such cases.

Test Details

New York Approved