Androgen Receptor Immunostain, Technical Component Only
Use
The test is useful for the identification of tumors that express androgen receptor. Androgen receptor binds testosterone and 5 alpha-dihydrotestosterone and mediates the biologic action of these sex hormones. It is normally expressed in various tissues, including the epithelium and stromal cells of the prostate, endometrium, ovary, and breast. Cells of meningiomas and the pituitary gland may also be positive.
Special Instructions
This test includes only the technical performance of the stain; no pathologist interpretation is provided. Technical component only stains should not be ordered with PATHC/Pathology Consultation. If ordered with PATHC, the technical component stains will be canceled. Clients wishing to access digital images must place the order for IHC stains electronically.
Limitations
Age of a cut paraffin section can affect immunoreactivity. Stability thresholds vary widely among published literature and are antigen dependent. Best practice is for paraffin sections to be cut within 6 weeks. The charge of glass slides can be affected by environmental factors and subsequently may alter slide staining. Sending unsuitable glass slides can result in inconsistent staining due to poor slide surface chemistry.
New York Approved
Methodology
Immunoassay (IHC)
Biomarkers
LOINC Codes
- Order only;no result
Result Turnaround Time
1-3 days
Related Documents
For more information, please review the documents below
Specimen
Tissue (FFPE)
Volume
Not provided
Minimum Volume
Not provided
Container
Immunostain Technical Only Envelope
Collection Instructions
Formalin-fixed, paraffin-embedded tissue block OR 2 unstained, positively charged glass slides (25 x 75 x 1-mm) per test ordered; sections 4-microns thick
Storage Instructions
Attach the green pathology address label and the pink Immunostain Technical Only label included in the kit to the outside of the transport container.
Causes for Rejection
Wet/frozen tissue, cytology smears, nonformalin fixed tissue, nonparaffin embedded tissue, noncharged slides, ProbeOn slides, Snowcoat slides